U218 Singles' released in 2006, was the 'definitive best of', the first single disc collection to span the band's career from Boy (1980) to How To Dismantle An Atomic Bomb (2004). At the same time, U218 Videos was released, a DVD featuring music videos from throughout U2's career. Featuring sixteen singles from the more than forty then released by the band, the album also included two new songs both recorded at Abbey Road Studios in London in September 2006 and produced by Rick Rubin.

'The Saints Are Coming', a cover of the 1978 Skids track, was recorded with Green Day, debuted live a few days later at the reopening of the New Orleans Dome and proceeds from worldwide sales went to Music Rising, a charity set up by Edge to 'help bring the music back to New Orleans' . Released as a 2 track CD, maxi CD, and DVD single, the b-side was a performance of Tower of Song, recorded with Leonard Cohen, for the movie 'Leonard Cohen: I'm Your Man'.

'Window In the Skies' was a brand new U2 song, written and recorded at Abbey Road and released as a single in early 2007. It was described by Bono as 'a psychedelic pop song with 6/8 timing, you never hear that. It's very, very rare.' Nominated in the 'Best Pop Performance By A Duo Or Group With Vocals' category at the 2007 Grammy Awards, the band performed 'Window' live for the first time in Japan on the Vertigo 06 Tour.